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Octet® BLI Advancing GLP-1 Analog Development
Glucagon-like peptide-1 (GLP-1) receptor agonists, once diabetes treatments, have exploded into popular culture as a powerful weight-loss medicine. With oral formulations now reaching the market, GLP-1s may turn out to be the drug class of a decade.
Our latest app note outlines structure–function methods and Octet® BLI workflows to measure binding kinetics and affinity for Victoza® (liraglutide), Trulicity® (dulaglutide), and Ozempic® (semaglutide). Therapeutic researchers can learn how amino‑acid and fatty‑acid modifications enhance stability & efficacy, with one analog showing higher affinity than its competitors.
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Dr. Florian Funck
Dr. René Fáber
Dr. Alexandra Gatzemeyer
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